RNA INTERFERENCE MEDIATED INHIBITION OF HUMAN IMMU

专利名称：RNA INTERFERENCE MEDIATED INHIBITION

OF HUMAN IMMUNODEFICIENCY VIRUS(HIV) GENE EXPRESSION USING SHORTINTERFERING NUCLEIC ACID (siNA)

发明人：Leonid Beigelman,James McSwiggen申请号：US13179785申请日：20110711

公开号：US20120041184A1公开日：20120216

摘要：This invention relates to compounds, compositions, and methods useful formodulating human immunodeficiency virus (HIV) gene expression using short interferingnucleic acid (siNA) molecules. This invention also relates to compounds, compositions,and methods useful for modulating the expression and activity of other genes involved inpathways of human immunodeficiency virus (HIV) gene expression and/or activity by RNAinterference (RNAi) using small nucleic acid molecules. In particular, the instant inventionfeatures small nucleic acid molecules, such as short interfering nucleic acid (siNA), shortinterfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and shorthairpin RNA (shRNA) molecules and methods used to modulate the expression of HIVgenes. The small nucleic acid molecules are useful in the treatment of HIV infection, AIDS,and/or diseases and conditions related to HIV infection and/or AIDS in a subject ororganism.

申请人：Leonid Beigelman,James McSwiggen

地址：San Mateo CA US,Bothell WA US

国籍：US,US

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