4-(3-BENZYLOXYPHENYLTHIO)-2-CHLORO-1-(3-NITROPROPY

专利名称：4-(3-BENZYLOXYPHENYLTHIO)-2-CHLORO-1-(3-NITROPROPYL)BENZENE CRYSTAL

发明人：TSUBUKI, TAKESHI,SATO, HIROYA申请号：EP13778567申请日：20130417公开号：EP2840079A4公开日：20151118

摘要：4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene (compound 1) isused as an intermediate for producing a 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1-,3-propanediol hydrochloride which has excellent

immunosuppressive activity. This compound 1 is traditionally obtained only as an oil andthus handling and refining were difficult. [Solution] A crystal of the compound 1 isobtained. A method of crystallizing the same is also established. Furthermore, a simplerefining method is also found which comprises stirring in suspension the crystal in asolvent. Since the compound 1 can be obtained as a crystal, it is easier to handle and longterm storage is possible.

申请人：KYORIN PHARMACEUTICAL CO., LTD.

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