专利名称：Method for the production of optically
active 3-alkylcarboxylic acids and theintermediate products thereof
发明人：Klas Sorger,Jürgen Stohrer申请号：US11569452申请日：20050512公开号：US07534908B2公开日：20090519
摘要：An enantioselective method for producing optically active 3-alkyl carboxylicacids comprises transforming an optically active secondary alcohol into an opticallyactive, activated compound by introducing a leaving group; reacting the activatedcompound with a malonic acid derivative to obtain an optically active, alkylated malonicacid compound, the reaction taking place exclusively in ether and/or carboxylic acid estersolvents and one or more aprotic polar solvents or alcohols as a cosolvent in a maximumproportion of 30 volume percent of total solvent, wherein the added cosolvent is nothexamethyl phosphoric acid triamide; the malonic acid compound is hydrolyzed ifnecessary to obtain the corresponding acid; and the corresponding acid isdecarboxylated.
申请人：Klas Sorger,Jürgen Stohrer
地址：München DE,Pullach DE
国籍：DE,DE
代理机构：Brooks Kushman P.C.
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