IMPROVED PROCESS FOR ISOLATION AND PURIFICATION OF

专利名称：IMPROVED PROCESS FOR ISOLATION AND

PURIFICATION OF PACLITAXEL FROMNATURAL SOURCES

发明人：BUI-KHAC, Trung,POTIER, Michel申请号：EP04705360.8申请日：20040127公开号：EP1608636A1公开日：20051228

摘要：Disclosed is a process for isolating and purifying paclitaxel from a naturalresource of taxanes, comprising the steps of (a) washing a raw material comprisingpaclitaxel with water in order to remove soluble impurities from the raw material; (b)extracting with an organic solvent a wet raw material comprising paclitaxel; (c) contactingthe wet raw material with a salt to obtain a biomass by precipitation, isolation, and drying;(d) removing resin and natural pigments from the dried biomass by dissolving thebiomass in acetone or an acetone-hexane mixture, and adding at least one polar solventuntil a paclitaxel-enriched oil phase is obtained; and (e) chromatography purifying thepaclitaxel-enriched oil phase in a volatile solvent to obtain a purified solution, followedby crystallization.

申请人：Chaichem Pharmaceuticals International

地址：230 Bernard Belleau, Suite 130 Laval,Québec H7V 4A9 CA

国籍：CA

代理机构：Khairallah, Murielle

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